I have a PRS S2 Standard 22. It has a mahogany body and neck with rosewood fretboard. The 85/15 S stock pickups are good, but I think they are not for my style of playing. I was thinking of the Seymour Duncan Custom 5 bridge and Jazz neck, but I haven't tried DiMarzios yet! So, I thought of giving it try!
I personally don't like the custom 5. It can get thin very quick. Even on a warmer guitar I have I have found it to be the case. On the Duncan side of things, I have tried a JB (can get shrill quick and to my ears and being that I have it in two guitars, sounds better with a 250k setup than a 500k for controls). The Full Shred (Articulate and kind of a medium output articulate and tight). PG + Kind of a full sound, not terribly high on output, but distorts nice (overwound Pearly Gates with an a5 magnet vs the a2. Some claim it is shrill but I have found it to not be the case in my Big Apple Strat with a rosewood fretboard).
I have used the X2N and I have never found it to be dark or bright. Kind of balanced, but BRUTAL on the amps input. Do NOT expect chimey cleans from it full on. BUT, parallel and split sound very good clean to my ears.
How much available preamp gain to you have? The reason that I ask is that if you DO have a good amount of preamp gain, then maybe a moderate output pickup might be better suited for you. I used to use nothing but high output bridge pickups, but found that the versatility and articulation of a moderate output pickup works better for me. And by the way, I also do a lot of high gain stuff. Check out my instrumentals at
www.acadams.bandcamp.comAnyhow, the moderate output thing is just a suggestion. Don't pigeon hole yourself into thinking that you absolutely need a serious high output pickup. You may find just the opposite.